Multi-Omics Testing for Immunotherapy Efficacy Evaluation (MOTIVATION)

Inclusion Criteria: * Patients with stage I-IV non-small cell lung cancer(with no restriction of age, gender, or smoking history) * Patients in the group will be allowed to collect whole blood and tissue samples at specific time points * Eastern Cooperative Oncology Group Performance Status of 0-1 within 28 days prior to registration * No previous systemic anti-tumor therapy * Signed informed consent Exclusion Criteria: * Active or history of autoimmune disease or immune deficiency * Patients with serious mental disease * Prior allogeneic stem cell or solid organ transplantation * Pregnant or lactating women * Patients who cannot obtain tumor tissue samples and / or whole blood * Patients with history of blood transfusion within half a year * Patients with any other malignancy diagnosed within 5 years * Received systemic anti-tumor therapy