The study evaluates the pharmacokinetics (PK), safety and tolerability of oxfendazole, after administration as a tablet formulation in healthy male and female participants.
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Area under the plasma concentration curve from time zero to the last quantifiable concentration at time t (AUC0-t) of oxfendazole and its metabolites fenbendazole and fenbendazole sulfone
Timeframe: At different time points from pre-dose up to 48 hours after single dose administration
Area under the plasma concentration curve (AUC) from time zero extrapolated to infinity (AUC0-∞) of oxfendazole and its metabolites fenbendazole and fenbendazole sulfone
Timeframe: At different time points from pre-dose up to 48 hours after single dose administration
Maximum observed concentration (Cmax) of oxfendazole and its metabolites fenbendazole and fenbendazole sulfone
Timeframe: At different time points from pre-dose up to 48 hours after single dose administration
Time to maximum observed concentration (Tmax) of oxfendazole and its metabolites fenbendazole and fenbendazole sulfone
Timeframe: At different time points from pre-dose up to 48 hours after single dose administration
Elimination half-life (t1/2) of oxfendazole and its metabolites fenbendazole and fenbendazole sulfone
Timeframe: At different time points from pre-dose up to 48 hours after single dose administration
Area under the plasma concentration curve over dosing interval (AUCtau) of oxfendazole and its metabolites fenbendazole
Timeframe: At different time points from pre-dose up to 72 hours after last dose administration
Accumulation Ratio (Racc) of oxfendazole and its metabolites fenbendazole
Timeframe: At different time points from pre-dose up to 72 hours after last dose administration
Maximum observed concentration (Cmax) of oxfendazole and its metabolites fenbendazole and fenbendazole sulfone
Timeframe: At different time points from pre-dose up to 72 hours after last dose administration
Time to maximum observed concentration (Tmax) of oxfendazole and its metabolites fenbendazole and fenbendazole sulfone
Timeframe: At different time points from pre-dose up to 72 hours after last dose administration
Elimination half-life (t1/2) of oxfendazole and its metabolites fenbendazole and fenbendazole sulfone
Timeframe: At different time points from pre-dose up to 72 hours after last dose administration