Primary Lymphedema and Mutation CELSR1 (Cadherin EGF LAG Seven-pass G-type Receptor 1)

Inclusion criteria: * Patient followed up in vascular medicine departement at Montpellier University Hospital for primary lymphedema of lower limbs, who carries the CELSR1 mutation with codon stop or amino acids substitution mechanism. * Relatives to the index case who carry the mutation for the segregation study. Exclusion criteria: * Patients who carry another mutation than CELSR1 responsible for primary lymphedema * Syndromic form of primary lymphedema * Patient not followed up at Montpellier University Hospital.