Active — Not RecruitingPhase 2

The COlchicine HypERtENsion Trial

Denmark150 participantsStarted 2021-08-10

Plain-language summary

The purpose of this study to investigate the effects of colchicine on measures of vascular and cardiac function in patients with hypertension.

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

✕. Colchicine treatment for another cause, e.g. gout
✕. Allergy/hypersensitivity to colchicine
✕. Known or suspected secondary hypertension, e.g. renal artery stenosis
✕. Uncontrolled hypertension (systolic BP \>180 mmHg or diastolic BP \>110 mmHg)
✕. Known other cardiovascular disease (judged by the investigator), e.g. ischemic heart disease, heart failure, significant valvular disease, arrhythmia, stroke, or peripheral artery disease
✕. History of malignancy of any organ system excluding a successfully treated non-metastatic cutaneous squamous cell or basal cell carcinoma, localized prostate cancer and/or localized carcinoma in situ of the cervix
✕. Cirrhosis, chronic active hepatitis or other severe hepatic disease
✕. Hemodialysis

Between-group difference in change in carotid-femoral pulse wave velocity at 6 months

Timeframe: 6 months

NCT IDNCT04916522

SponsorHerlev and Gentofte Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-01