CompletedPhase 4

Postoperative Pain Relief With Transversus Thoracis Muscle Plane Block After Cardiac Surgery

Finland120 participantsStarted 2021-10-15

Plain-language summary

This study aims to investigate the effect of transversus thoracis muscle plane block (TTP), using repeated boluses of ropivacaine via catheter, on postoperative pain and oxycodone consumption after elective cardiac surgery with sternotomy.

Who can participate

Age range18 Years – 80 Years

SexALL

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Inclusion criteria

✓. 18 - 80 years of age
✓. The patient is scheduled for open cardiac coronary arterial bypass graft (CABG) OR single heart valve surgery that require median sternotomy under general anesthesia
✓. Patients that are estimated to be weaned from mechanical ventilator not later than 8 h after surgery
✓. Patients that are capable of using the patient controlled analgesia device (PCA) after surgery
✓. Written informed consent from the patient

Exclusion criteria

✕. A previous history of intolerance to the study drug or related compounds and additives
✕. Redo surgery
✕. Combined CABG and heart valve surgery
✕. Endocarditis and/or mediastinitis.
✕. Concomitant drug therapy with strong opioids or strong CYP3A4 or CYP2D6 inductor(s) or inhibitor(s) 2 weeks prior to study.
✕. Patients younger than 18 years or older than 80 years.
✕. Body weight \< 60 kg
✕. BMI \> 35, sleep apnoea, any other sleep disorder or condition that requires treatment with continuous positive airway pressure or automatic positive airway pressure device.

What they're measuring

Number of patients with satisfactory pain response measured with visual rating scale (VAS)

Timeframe: 72 hours

Trial details

NCT IDNCT04916418

SponsorTurku University Hospital

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2023-12-01

View on ClinicalTrials.gov More Pain, Postoperative trials