RecruitingNot Applicable

Examining the Impact of Exercise Training on Vascular Dysfunction in Individuals With Mental Health Disorders - Study 1

United States720 participantsStarted 2021-08-23

Plain-language summary

The purpose of this research study is to examine the role oxidants, substances produced in the blood that can damage blood vessel function, may play in blood vessel function in healthy individuals as well as individuals with mental health disorders (posttraumatic stress disorder (PTSD) and/or generalized anxiety disorder (GAD)).

Who can participate

Age range18 Years – 35 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * apparently healthy and free of overt cardiovascular, pulmonary, or metabolic disease * for PTSD group, a score of ≥ 33 on PCL-5 checklist * for GAD group, a score of ≥ 10 on the GAD-7 self-report scale and \< 33 on the PCL-5 checklist * for Healthy Control group, a score of ≤ 10 on the GAD-7 self-report scale and \< 33 on the PCL-5 checklist Exclusion Criteria: * taking medications that could influence cardiovascular function * current smokers who have recently quit smoking * illicit drug use or excessive alcohol consumption * pregnant women * significant calorie restriction or vitamin/mineral deficiencies * limited English proficiency

What they're measuring

Arm Vascular Function at Rest (Flow Mediated Dilation Test)

Timeframe: Baseline to the end of the final visit, about 2 weeks

Leg Vascular Function (Passive Leg Movement Test)

Timeframe: Baseline to the end of the final visit, about 2 weeks

Arm Vascular Function in Response to Exercise (Handgrip Exercise Test)

Timeframe: Baseline to the end of the final visit, about 2 weeks

Trial details

NCT IDNCT04916327

SponsorVirginia Commonwealth University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-05

Contact for this trial

Ryan Garten, PhD

(804) 828-1948 rsgarten@vcu.edu

View on ClinicalTrials.gov More Peripheral Vascular Diseases trials

Plain-language summary

Who can participate

Age range18 Years – 35 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Arm Vascular Function at Rest (Flow Mediated Dilation Test)

Timeframe: Baseline to the end of the final visit, about 2 weeks

Leg Vascular Function (Passive Leg Movement Test)

Timeframe: Baseline to the end of the final visit, about 2 weeks

Arm Vascular Function in Response to Exercise (Handgrip Exercise Test)

Timeframe: Baseline to the end of the final visit, about 2 weeks