UnknownPhase 4

The Role of Tranexamic Acid in Reducing Post Operative Hand Edema After Hand and Wrist Surgery

Canada50 participantsStarted 2021-06-01

Plain-language summary

Hand edema following hand surgery is a common yet devastating side effect that can lead to early stiffness, prolonged rehabilitation and diminished function. These factors can reduce a patient's quality of life; mounting to an overall delay in recovery, return to work and daily activities. Conventional edema therapy includes cryotherapy, external compression, active and passive exercises and various types of massage. However, there is little evidence to suggest these modalities are effective. Tranexamic acid (TXA) is an antifibrinolytic that has been used in surgical disciplines for decades to aid in reducing intraoperative blood loss and consequent transfusions. Recently, the use of TXA for curbing post-operative edema and ecchymosis has shown promising results, however, its use in hand surgery has not been studied.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * All patients \>18 years old undergoing distal radius fracture open reduction and internal fixation through a volar approach at St. Joseph's hospital in London, Ontario * All patients \>18 years old undergoing open fasciectomy for Dupuytren's disease at St. Joseph's hospital in London, Ontario Exclusion Criteria: * Revision surgery * Distal radius fractures treated with additive or alternative approaches and fixation to the volar approach * Known history of lymphedema or lymph node dissection on either upper extremity * Known allergic reaction to TXA * Cardiovascular problems (history of myocardial infraction, angina, and atrial fibrillation) * Cerebrovascular conditions (history of previous stroke) * Thromboembolic disorders (history of deep vein thrombosis \[DVT\] or pulmonary embolism \[PE\]), clotting disorders) * Known seizure disorder * Currently on dialysis * Current pregnancy or breastfeeding * Current use of hormone contraception * Unable to read consent and patient surveys related to the study in English

What they're measuring

Adherence to protocol

Timeframe: 12 weeks

Treatment Completion Rate

Timeframe: 12 weeks

Retention Rate

Timeframe: 12 weeks

Recruitment rate

Timeframe: 12 weeks

Trial details

NCT IDNCT04907812

SponsorRuby Grewal

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-12-01

View on ClinicalTrials.gov More Hand Injuries and Disorders trials

Plain-language summary

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.