The Role of Tranexamic Acid in Reducing Post Operative Hand Edema After Hand and Wrist Surgery (NCT04907812) | Clinical Trial Compass
UnknownPhase 4
The Role of Tranexamic Acid in Reducing Post Operative Hand Edema After Hand and Wrist Surgery
Canada50 participantsStarted 2021-06-01
Plain-language summary
Hand edema following hand surgery is a common yet devastating side effect that can lead to early stiffness, prolonged rehabilitation and diminished function. These factors can reduce a patient's quality of life; mounting to an overall delay in recovery, return to work and daily activities. Conventional edema therapy includes cryotherapy, external compression, active and passive exercises and various types of massage. However, there is little evidence to suggest these modalities are effective. Tranexamic acid (TXA) is an antifibrinolytic that has been used in surgical disciplines for decades to aid in reducing intraoperative blood loss and consequent transfusions. Recently, the use of TXA for curbing post-operative edema and ecchymosis has shown promising results, however, its use in hand surgery has not been studied.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* All patients \>18 years old undergoing distal radius fracture open reduction and internal fixation through a volar approach at St. Joseph's hospital in London, Ontario
* All patients \>18 years old undergoing open fasciectomy for Dupuytren's disease at St. Joseph's hospital in London, Ontario
Exclusion Criteria:
* Revision surgery
* Distal radius fractures treated with additive or alternative approaches and fixation to the volar approach
* Known history of lymphedema or lymph node dissection on either upper extremity
* Known allergic reaction to TXA
* Cardiovascular problems (history of myocardial infraction, angina, and atrial fibrillation)
* Cerebrovascular conditions (history of previous stroke)
* Thromboembolic disorders (history of deep vein thrombosis \[DVT\] or pulmonary embolism \[PE\]), clotting disorders)
* Known seizure disorder
* Currently on dialysis
* Current pregnancy or breastfeeding
* Current use of hormone contraception
* Unable to read consent and patient surveys related to the study in English
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.