Osteoarthritis (OA) is a leading cause of disability worldwide that affects millions of Americans each year. Posttraumatic OA (PTOA) significantly impacts patients after anterior cruciate ligament (ACL) injury and ACL reconstruction (ACLR) with approximately 50% of patients developing PTOA within 20 years of injury or surgery. Knee joint mechanical loading measured via physical activity (i.e. daily steps) is insufficient in individuals after ACLR compared to uninjured individuals. Establishing the beneficial effects of physical activity to promote optimal free-living knee joint mechanical loading and improve knee joint health will aid in the development of cost-effective interventions that prevent PTOA and health burden of the disease.
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T1rho Relaxation Times in the Medial Femoral Condyle at Baseline
Timeframe: pre-intervention (baseline)
T1rho Relaxation Times in the Medial Femoral Condyle Post-intervention
Timeframe: post-intervention (~8 weeks)
T1rho Relaxation Times in the Lateral Femoral Condyle at Baseline
Timeframe: pre-intervention (baseline)
T1rho Relaxation Times in the Lateral Femoral Condyle Post-intervention
Timeframe: post-intervention (~8 weeks)
T1rho Relaxation Times in the Medial Tibial Condyle at Baseline
Timeframe: pre-intervention (baseline)
T1rho Relaxation Times in the Medial Tibial Condyle Post-intervention
Timeframe: post-intervention (~8 weeks)
T1rho Relaxation Times in the Lateral Tibial Condyle at Baseline
Timeframe: pre-intervention (baseline)
T1rho Relaxation Times in the Lateral Tibial Condyle Post-intervention
Timeframe: post-intervention (~8 weeks)
Change in Daily Steps
Timeframe: pre-intervention (baseline), post-intervention (~8 weeks)
Change in T1rho Relaxation Times in the Medial Femoral Condyle
Timeframe: pre-intervention (baseline), post-intervention (~8 weeks)
Change in T1rho Relaxation Times in the Medial Tibial Condyle
Timeframe: pre-intervention (baseline), post-intervention (~8 weeks)
Change in T1rho Relaxation Times in the Lateral Femoral Condyle
Timeframe: pre-intervention (baseline), post-intervention (~8 weeks)
Change in T1rho Relaxation Times in the Lateral Tibial Condyle
Timeframe: pre-intervention (baseline), post-intervention (~8 weeks)