Osteoarthritis (OA) is a leading cause of disability worldwide that affects millions of Americans each year. Posttraumatic OA (PTOA) significantly impacts patients after anterior cruciate ligament (ACL) injury and ACL reconstruction (ACLR) with approximately 50% of patients developing PTOA within 20 years of injury or surgery. Knee joint mechanical loading measured via physical activity (i.e. daily steps) is insufficient in individuals after ACLR compared to uninjured individuals. Establishing the beneficial effects of physical activity to promote optimal free-living knee joint mechanical loading and improve knee joint health will aid in the development of cost-effective interventions that prevent PTOA and health burden of the disease.
Age range
18 Years – 35 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
T1rho Relaxation Times in the Medial Femoral Condyle at Baseline
Timeframe: pre-intervention (baseline)
T1rho Relaxation Times in the Medial Femoral Condyle Post-intervention
Timeframe: post-intervention (~8 weeks)
T1rho Relaxation Times in the Lateral Femoral Condyle at Baseline
Timeframe: pre-intervention (baseline)
T1rho Relaxation Times in the Lateral Femoral Condyle Post-intervention
Timeframe: post-intervention (~8 weeks)
T1rho Relaxation Times in the Medial Tibial Condyle at Baseline
Timeframe: pre-intervention (baseline)
T1rho Relaxation Times in the Medial Tibial Condyle Post-intervention
Timeframe: post-intervention (~8 weeks)
T1rho Relaxation Times in the Lateral Tibial Condyle at Baseline
Timeframe: pre-intervention (baseline)
T1rho Relaxation Times in the Lateral Tibial Condyle Post-intervention
Timeframe: post-intervention (~8 weeks)
Change in Daily Steps
Timeframe: pre-intervention (baseline), post-intervention (~8 weeks)
Change in T1rho Relaxation Times in the Medial Femoral Condyle
Timeframe: pre-intervention (baseline), post-intervention (~8 weeks)
Change in T1rho Relaxation Times in the Medial Tibial Condyle
Timeframe: pre-intervention (baseline), post-intervention (~8 weeks)
Change in T1rho Relaxation Times in the Lateral Femoral Condyle
Timeframe: pre-intervention (baseline), post-intervention (~8 weeks)
Change in T1rho Relaxation Times in the Lateral Tibial Condyle
Timeframe: pre-intervention (baseline), post-intervention (~8 weeks)