The Use of Amniotic Membrane or Internal Limiting Membrane for Large or Refractory Macular Holes: A Prospective Study

Inclusion Criteria: * Patients with a macula hole that falls into the two categories below: * Patients with idiopathic macular hole (with no history of secondary macular hole) ≥ 600 microns (measured using optical coherence tomography) * Patients with an idiopathic macular hole submitted to conventional treatment without closing it (of any size). * History of the disease less than 18 months * Aged over 18 years old * Visual acuity less than 20/32 Exclusion Criteria: * History of any previous macular disease other than idiopathic macular hole * Macular hole of other causes (secondary) * Patients with diabetic retinopathy or other retinal vascular diseases * Eyes subjected to intravitreal injection of any medication * Visual acuity \<20/400 of any retinal cause in the contralateral eye or absence of the globe \*Aged under 50 years old * Cataract and anti-glaucoma surgery less than 3 months before the study * Glaucoma with optic nerve excavation \> 0.7 in the studied eye * Intraocular pressure \> 24 mmHg with the use of maximum medication in the studied eye * History of vitreoretinal surgery for a condition other than the idiopathic macular hole (retinal detachment, vitreous hemorrhage) * History of retinal detachment of any etiology * A patient who manifests himself not being able to perform the head position in the postoperative period * A patient with active anterior or posterior uveitis