CompletedNot Applicable

Effects of Low/No Calorie Sweeteners on Glucose Tolerance

Turkey (Türkiye)42 participantsStarted 2019-04-02

Plain-language summary

This study aims to determine the effects of chronic exposure to some low/no calorie sweeteners (LNCS) on glucose tolerance and glucagon like peptide 1 (GLP-1) release in healthy individuals. LNCS examined in this study are saccharin, sucralose and aspartame+acesulfame-K. The amounts of LNCS given to the participants are kept similar to daily life exposure; far less than the Acceptable Daily Intakes (ADIs) levels proposed by Food and Drug Administration (FDA) or European Food Safety Authority (EFSA).

Who can participate

Age range19 Years – 45 Years

SexFEMALE

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Inclusion Criteria: * Healthy, * Normoglycemic, * Female, * 19-45 years old, * Weight-stable past 3 months Exclusion Criteria: * Insulin resistance, * Type 2 diabetes mellitus, * Presence of acute/chronic infection, * Use of medication that may affect glucose metabolism (thiazide diuretics, glucocorticoids, estrogen or beta blockers) * Chronic alcohol intake, * Regular consumption of diet soda (more than one can of soda per week)

What they're measuring

3 Hours Plasma Glucose

Timeframe: 3 hours

3 Hours Plasma Insulin

Timeframe: 3 hours

Glucagon-like peptide-1 (GLP-1) release

Timeframe: Week 4

Trial details

NCT IDNCT04904133

SponsorAcibadem University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-05-12

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