Cellular Senescence and COVID-19 Long-Hauler Syndrome
United States200 participantsStarted 2021-03-01
Plain-language summary
The purpose of this study is to test if senescent cells and their secretome contribute to Long-Hauler Syndrome and if a clinical trial of senolytic drugs, which selectively eliminate senescent cells, should be initiated.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Longhauler's Cohort -
Inclusion Criteria:
* Ability to give informed consent or LAR.
* At least 18 years old.
* Ability of subject or LAR to read and speak the English language.
* Positive PCR or antibody test within 12 months of initial study visit.
* Patient of the Long-Hauler Syndrome clinic and differential diagnosis of Long-Hauler Syndrome.
Exclusion Criteria:
* Any potential participant who refuses medical record review.
* Pregnant females.
* Incarcerated individuals.
* Inability to cooperate or any medical condition that, in the opinion of the investigator, interferes with the evaluation of the study objectives or increases the subject's risk by participating in the study.
Control Cohort -
Inclusion Criteria:
* Ability to give informed consent
* At least 18 years old
* Ability of subject to read and speak the English language
Exclusion Criteria:
* Known case of COVID-19.
* Any potential participant who refuses medical record review.
* Pregnant females.
* Incarcerated individuals.
* Inability to cooperate or any medical condition that interferes with the evaluation of the study objectives or increases the subject's risk by participating in the study.
COVID-19 Control Cohort
Inclusion Criteria:
* Ability to give informed consent.
* At least 18 years old.
* Ability of subject to read and speak the English language.
* Known case of COVID-19.
Exclusion Criteria:
* Known Longhauler's syndrome/Post-COVID
* Any potential participant who refuses medical record rev…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Correlation between features of Long-Hauler Syndrome with markers of cellular senescence and SASP factors