Plinabulin in Combination With Radiation/Immunotherapy in Patients With Select Advanced Cancers After Progression on PD-1 or PD-L1 Targeted Antibodies

Inclusion Criteria: * Subjects must have one of seven histologically or cytologically confirmed malignant neoplasms (non-small cell lung cancer, small cell lung cancer, renal cell cancer, bladder cancer, Merkle cell cancer, microsatellite instability high (MSI-H) cancer (any histology), and melanoma) progressed on previous anti-PD-1/PD-L1 mAb treatment +/- chemotherapy or anti-CTLA4 requiring further treatment * At least one lesion is amenable to radiation * At least one additional non-contiguous lesion that has not been irradiated amenable to radiographic evaluation * Have measurable disease based on immune-related response criteria (immune-related Response Evaluation Criteria In Solid Tumors \[RECIST\]) * Tissue must be newly obtained as a core needle biopsy (not fine-needle aspiration \[FNA\]) of the lesion being evaluated * Age \>= 18 years * Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 * Subjects must be recovered from any prior major surgery. The major surgery must be performed at least 4 weeks prior to consent date * Platelets \>= 100 x 10\^9/L * Transfusions and growth factors are allowed * Hemoglobin \>= 9 g/dL * Transfusions and growth factors are allowed * Absolute neutrophil count (ANC) \>= 1.5 x 10\^9/L * Transfusions and growth factors are allowed * White blood cell (WBC) \>= 3 x 10\^9/L * Transfusions and growth factors are allowed * Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =\< 2.5 x upper limit of …