CompletedNot Applicable

Esophageal Atresia: a Natural Experiment of the Effects of Oral Inoculation on the Gut Microbiome

United States52 participantsStarted 2021-05-15

Plain-language summary

The purpose of this study is to understand changes of the gut microbiome due to esophageal atresia. The intervention will be to give a patient his or her own saliva through their gastrostomy tube (directly into the stomach) to observe if this can normalize microbial colonization of the gut.

Who can participate

Age range3 Months

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Neonates with Esophageal Atresia (All, no exclusion criteria); maximum age at enrollment is 3 months. * Neonates matched for gestational age without EA, also anticipated to require surgery (Infants \>=32 weeks), or also premature (\<32 weeks) Exclusion Criteria (only for infants without EA): * sepsis * admission to study hospital after 7 days old * expected length of stay \<2 weeks

What they're measuring

Change in Gut Microbial Community Structure

Timeframe: From birth until discharge from the hospital, up to 1 year

Trial details

NCT IDNCT04901546

SponsorStanford University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-04-08

View on ClinicalTrials.gov More Esophageal Atresia trials