UnknownNot Applicable

POWER Myocardial Fatigue Study: a Biomechanical Assessment of Contractility of Human Myocardium

United Kingdom100 participantsStarted 2021-08-03

Plain-language summary

To gain a comprehensive understanding of the biomechanical behaviour of human heart to explore the concept of myocardial fatigue in response to a temporal range of preload, afterload and drug-induced inotropy using in-vitro contractile assays.

Who can participate

Age range

18 Years – 85 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * All adult patients between 18 to 85-years old undergoing open-heart surgery who can undergo the consent process for the study * Healthy donor hearts that are deemed non-transplantable and consent received from a legal representative Exclusion Criteria: This criterion is kept to a minimum since the availability of human myocardial samples is finite and dependent on the limited number of patients undergoing cardiac surgery annually within the local hospital. * Patients who do not have the mental capacity to undergo the consent process * For the safety of researchers, patients with evidence of ongoing blood-borne infections such as HIV, or a recent positive test for COVID-19 (within 10 days of last PCR test).

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Changes in the force generated by the muscle cell and/or muscle slice

Timeframe: Within a day for each experiment

Changes in the velocity of shortening by the muscle cell and/or muscle slice

Timeframe: Within a day for each experiment

Changes in the end-systolic force-length relationship of the muscle cell and/or muscle slice

Timeframe: Within a day for each experiment

Trial details

NCT IDNCT04899635

SponsorUniversity Hospitals Coventry and Warwickshire NHS Trust

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-04-30

Contact for this trial

Patrick Tran

02476964000 patricktranphd@gmail.com

View on ClinicalTrials.gov More Heart Failure trials

Who can participate

Age range

18 Years – 85 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Changes in the force generated by the muscle cell and/or muscle slice

Timeframe: Within a day for each experiment

Changes in the velocity of shortening by the muscle cell and/or muscle slice

Timeframe: Within a day for each experiment

Changes in the end-systolic force-length relationship of the muscle cell and/or muscle slice

Timeframe: Within a day for each experiment