Eosinophils in Human Adipose Tissue

Inclusion Criteria: * Obesity (BMI\>30 kg/m2). * Evidence of insulin resistance as defined by hemoglobin A1c \> 5.7%. * Mayo Clinic patients evaluated by Dr. Rahul Pannala. * Pursue an endoscopic gastroplasty at Mayo Clinic Arizona in the Gastroenterology department. * Equal distribution of gender. * 18 yo older of age. * BMI\>30 kg/m2. * Nonsmoker. * Taking no medication affecting glucose or lipid metabolism. * No more than 5% change in body weight in the previous 6 months. * Mostly sedentary (engaging in strenuous exercise (\> 70% max HR) less than 3 times a week). * Not be receiving corticosteroid therapy. * Have no history of asthma, COPD or atopic syndrome, or autoimmune disease (Ulcerative colitis, Chron's disease, eosinophilic esophagitis, any rheumatologic disease such as lupus, rheumatoid arthritis, Sjogren syndrome). Exclusion Criteria: * \<17 years of age. * BMI \<30 kg/m2. * Smoker. * Taking medication affecting glucose or lipid metabolism. * Greater than 5% change in body weight within the previous six months. * Engage in strenuous exercise (\>70% max HR) less than 3 times a week. * Receiving corticosteroid therapy. * Have a history of asthma. * History of COPD or atopic syndrome. * History of autoimmune disease (Ulcerative colitis, Chron's disease, eosinophilic esophagitis, any rheumatologic disease such as lupus, rheumatoid arthritis, Sjogren syndrome).