UnknownNot Applicable

Effect of Intraoperative Sedation on PND in Elderly Patients

160 participantsStarted 2021-07-01

Plain-language summary

The aim of this study was to identify the effects of different depths of sedation and choices of sedative drugs on perioperative neurocognitive disorders in the elderly patients receiving hip surgery under spinal anesthesia.

Who can participate

Age range65 Years

SexALL

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Inclusion criteria

✓. Acquisition of informed consent,
✓. Patients with hip fracture surgery under spinal anesthesia,
✓. Grade I to III based on American Society of Anesthesiologists ASA classification,
✓. Age ≥65.

Exclusion criteria

✕. There was a history of cardiovascular and cerebrovascular adverse events in the past six months, including myocardial infarction, angina pectoris, severe arrhythmia, stroke or transient ischemic attack (TIA)
✕. Heart failure (NYHA III / IV and / or LVEF \< 30%)
✕. Bradycardia
✕. Respiratory failure (need oxygen)
✕. Glasgow Coma Scale ≤ 14 points
✕. Severe hepatic and renal insufficiency (child Pugh grade B or C)
✕. Preoperative cognitive impairment or sedative drugs (benzodiazepines, etc.).
✕. Adverse reactions such as allergy to dexmedetomidine or / or propofol

What they're measuring

postoperative delirium

Timeframe: 1 week

Change from Cognitive state in 1 week.

Timeframe: 1 week

Trial details

NCT IDNCT04891458

SponsorHebei Medical University Third Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-06-30

Contact for this trial

Shuang Zhao, PhD

13613210924 zhaoshuang810924@163.com

View on ClinicalTrials.gov More Elderly trials