UnknownNot Applicable

Gut Microbiota in Patients With Moyamoya Disease

China120 participantsStarted 2021-05-01

Plain-language summary

This study is to find out the association between gut microbiota and moyamoya disease.

Who can participate

Age range

2 Years – 60 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Diagnosis of MMD by DSA according to the Japanese guidelines published in 2012,
. Stenosis or occlusion of the terminal internal carotid and the proximal middle and anterior cerebral arteries and unilateral or bilateral involvement
. Age: 2-60 years old.

Exclusion criteria

. Moyamoya syndrome,
. Pregnancy,
. Evidence of gastrointestinal infection/ inflammation/ obstruction
. History of partial or total resection of small or large bowel, as well as gut reanastomosis,
. Use of antibiotics within 2 weeks prior to symptoms onset,
. Gastrointestinal malignancy
. Any hospitalization within 3 months before recruitment

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Diversity analysis of genes and species between MMD patients and the control group

Timeframe: Through study completion，eight months.

Analysis of differences in intestinal microbiota between MMD patients and the control group

Timeframe: Through study completion，eight months.

Analysis of functional differences in the intestinal microbiota of MMD patients in comparison to the control group

Timeframe: Through study completion，eight months.

Analysis of metabolites of the intestinal microbiota of MMD patients in comparison to the control group

Timeframe: Through study completion，eight months.

Trial details

NCT IDNCT04890782

SponsorBeijing Tiantan Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2021-12-31

Contact for this trial

Dong Zhang, MD

13801121292 zhangdong0660@aliyun.com

View on ClinicalTrials.gov More Moyamoya Disease trials

Who can participate

Age range

2 Years – 60 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Diagnosis of MMD by DSA according to the Japanese guidelines published in 2012,
. Stenosis or occlusion of the terminal internal carotid and the proximal middle and anterior cerebral arteries and unilateral or bilateral involvement
. Age: 2-60 years old.

Exclusion criteria

. Moyamoya syndrome,
. Pregnancy,
. Evidence of gastrointestinal infection/ inflammation/ obstruction
. History of partial or total resection of small or large bowel, as well as gut reanastomosis,
. Use of antibiotics within 2 weeks prior to symptoms onset,
. Gastrointestinal malignancy
. Any hospitalization within 3 months before recruitment

What they're measuring

Diversity analysis of genes and species between MMD patients and the control group

Timeframe: Through study completion，eight months.

Analysis of differences in intestinal microbiota between MMD patients and the control group

Timeframe: Through study completion，eight months.

Analysis of functional differences in the intestinal microbiota of MMD patients in comparison to the control group

Timeframe: Through study completion，eight months.

Analysis of metabolites of the intestinal microbiota of MMD patients in comparison to the control group

Timeframe: Through study completion，eight months.