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Gut Microbiota in Patients With Moyamoya Disease

China120 participantsStarted 2021-05-01

Plain-language summary

This study is to find out the association between gut microbiota and moyamoya disease.

Age range2 Years – 60 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

✓. Diagnosis of MMD by DSA according to the Japanese guidelines published in 2012,
✓. Stenosis or occlusion of the terminal internal carotid and the proximal middle and anterior cerebral arteries and unilateral or bilateral involvement
✓. Age: 2-60 years old.

✕. Moyamoya syndrome,
✕. Pregnancy,
✕. Evidence of gastrointestinal infection/ inflammation/ obstruction
✕. History of partial or total resection of small or large bowel, as well as gut reanastomosis,
✕. Use of antibiotics within 2 weeks prior to symptoms onset,
✕. Gastrointestinal malignancy
✕. Any hospitalization within 3 months before recruitment

Diversity analysis of genes and species between MMD patients and the control group

Timeframe: Through study completion，eight months.

Analysis of differences in intestinal microbiota between MMD patients and the control group

Timeframe: Through study completion，eight months.

Analysis of functional differences in the intestinal microbiota of MMD patients in comparison to the control group

Timeframe: Through study completion，eight months.

Analysis of metabolites of the intestinal microbiota of MMD patients in comparison to the control group

Timeframe: Through study completion，eight months.

NCT IDNCT04890782

SponsorBeijing Tiantan Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2021-12-31

Dong Zhang, MD