B-cells ensure humoral immune response against antigens (Ag) thanks to their receptor (BCR). V(D)J rearrangement, somatic hypermutation, immunoglobulin (Ig) class switch and locus suicide recombination are mutational/recombinational processes targeting Ig loci influencing BCR expression. Study of these events is essential for B cell function analysis. Our project will provide the normal reference values using high throughput sequencing-based protocols.
Age range
18 Years – 70 Years
Sex
ALL
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Frequency of use of the V, D and J genes in VDJ rearrangements
Timeframe: through study completion, an average of 18 months