CompletedNot Applicable

Spontaneous Healing of ARticular Cartilage (SHARC)

United Kingdom15 participantsStarted 2018-09-01

Plain-language summary

SHARC is an observational study of cartilage patients who are treated with surgery that involves obtaining a harvest biopsy. SHARC will study the natural healing process of the harvest biopsy site based on histological and biochemical analyses of repair tissue biopsies, synovial fluid biomarkers, medical imaging (MRI) and gait analysis.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Being able to provide signed and dated informed consent form. * Scheduled for one of the following surgical treatments * Surgery that involves the harvest of cartilage tissue as part of the treatment, thus creating a fresh cartilage defect, which is then left to heal naturally. Examples of such surgery are autologous chondrocyte implantation (ACI) and mosaicplasty. * Autologous stromal cell implantation (ASCI), as part of the ASCOT randomised clinical trial. Exclusion Criteria: * Inadequate understanding of verbal explanations or written information given in English, or having special communication needs. * Chronic severe renal insufficiency * Anything that would preclude the individual's full compliance with or completion of the study.

What they're measuring

Fraction of hyaline cartilage in harvest repair tissue

Timeframe: 1 year after tissue harvest

Trial details

NCT IDNCT04889443

SponsorKeele University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2023-12-31

View on ClinicalTrials.gov More Cartilage Damage trials