Active — Not RecruitingNot Applicable

Testing the Effects of Exercise on Chemotherapy-Induced Peripheral Neuropathy

United States133 participantsStarted 2022-02-25

Plain-language summary

This phase II trial studies whether using exercise is better than the usual approach for treating chemotherapy-induced peripheral neuropathy (CIPN). CIPN occurs when chemotherapy damages the nerves communicating between the brain, spinal cord, and the rest of the body. The usual approach for treating CIPN is treatment with drugs that help reduce symptoms of other types of neuropathy (for example, from diabetes). However, these drugs do not treat all symptoms of CIPN. Exercise may help to reduce CIPN symptoms.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Have a diagnosis of cancer * Have received neurotoxic chemotherapy within the past nine months (could still be on chemotherapy or have already completed chemotherapy; i.e., taxane-, platinum-, vinca alkaloid-, epothilone-, or proteasome inhibitor-based chemotherapy * Report one or more symptoms of CIPN at a level of \>= 4 on the CIPN symptom inventory on the Screening Form * Have an Eastern Cooperative Oncology Group (ECOG) performance status 0-1 * Have at least six months life expectancy * Be at least 18 years of age * Be able to read and understand English * Be able to provide written informed consent Exclusion Criteria: * Have physical limitations (e.g., cardiorespiratory, orthopedic, central nervous system) that contraindicate participation in a low to moderate intensity home-based walking and progressive resistance exercise program, according to the participant's physician (e.g., oncologist, primary care) or physician's designee * Be identified as in the active or maintenance stage of exercise behavior per the Exercise Stages of Change Question on the Screening Form * Have planned surgery or radiation treatment during the course of the study (hormonal and biologic therapy is allowed) * Have contraindications for MRI scanning, per the MRI safety screening procedures of the MRI facility to be utilized for this participant * Are pregnant of have plans to become pregnant during the course of the study. Documentation of pregnancy and use of contracept…

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Chemotherapy-induced peripheral neuropathy (CIPN) symptom severity

Timeframe: Week 6 post randomization

Trial details

NCT IDNCT04888988

SponsorUniversity of Rochester NCORP Research Base

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-10-20

View on ClinicalTrials.gov More Chemotherapy-Induced Peripheral Neuropathy trials