COllaboration REsearch on Chronic Cough (COREC): a French Multicenter Database (NCT04882943) | Clinical Trial Compass
TerminatedNot Applicable
COllaboration REsearch on Chronic Cough (COREC): a French Multicenter Database
Stopped: The recruitment target has been revised downwards following recruitment problems in external centers.
France178 participantsStarted 2021-06-22
Plain-language summary
Chronic cough (TC), defined by a duration exceeding 8 weeks, is a particularly frequent symptom with a prevalence observed at 9.6% 1. Chronic cough is the cause of a major handicap for patients with a impact on their quality of life 2.
Although CT is common, management is often delicate and complex. In studies, asthma, gastroesophageal reflux disease, posterior flushing, rhino-sinusitis, or taking tussigenic medications are common causes of chronic coughs. However, chronic refractory or unexplained cough, which corresponds to cough for which no cause has been found or the treatments directed against the cause of the cough have not made it possible to resolve the cough, is a real problem in practice. nick3.
There is currently no prospective data in France on the characteristics of chronic cough (etiologies, response to treatment) and the percentage of refractory cough.
The aim of the study is to constitute a French prospective multicenter hospital cohort of chronic cough patients in order to identify, for the first time in France in a prospective and multicenter manner, the frequency of patients with refractory cough among chronic cough patients.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age ≥18 years old
* Consultation motivated by cough lasting for more than 8 weeks (duration corresponding to the definition of chronic cough)
* Patient covered by a National Health Insurance
Exclusion Criteria:
* Active smoker or recent smoking cessation (within the past 6 months)
* Intake of medications causing cough (the patient can be included 4 weeks after treatment discontinuation if cough persists)
* Pregnant or breast-feeding women
* Upper or lower respiratory tract infection within the past 4 weeks
* Active lung disease (such as interstitial lung disease, lung cancer, abnormal dilation of the bronchi).
* History of chronic bronchitis.
* Current treatment with an angiotensin converting enzyme (ACE) inhibitor
* History of cancer within the past 5 years or active cancer (excluding cutaneous squamous-cell carcinoma).
* Person not fluent in French
* Adult not able to express his/her consent verbally
* Patient refusal
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
French prospective multicenter hospital cohort of chronic cough patients (requency of patients with unexplained or refractory chronic cough (URCC)