TerminatedNot Applicable

Validation of Quantitative Myocardial Tissue Characterization Through Non-gated CT

Stopped: PI ceased activity

Italy33 participantsStarted 2021-05-07

Plain-language summary

The main aim is to validate non-gated 5-min computed tomography myocardial relative enhancement (CT-MRE), which can be readily estimated via contrast-enhanced non-gated chest CT, as a tool for estimating myocardial extracellular volume (ECV) using cardiac magnetic resonance (CMR)-derived ECV as a reference standard in a consecutive series of patients scheduled for cardiac CT. A secondary explorative aim is to evaluate the presence and extent of possible myocardial alterations in those patients enrolled in the VALETUDO study who have been infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Who can participate

Age range18 Years – 80 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients referred for contrast-enhanced cardiac CT * Age 18 to 80 years Exclusion Criteria: * Absolute contraindications to CMR * Implantable cardioverter defibrillators and ferromagnetic thoracic devices which may cause artifacts at magnetic resonance imaging * Previous allergic reactions to gadolinium-based contrast agents * Pregnancy * Severe obesity * Severe claustrophobia * Too low image quality to perform post-processing analyses

What they're measuring

Validation of CT-MRE as a surrogate of CMR-ECV

Timeframe: 3 months

Trial details

NCT IDNCT04880317

SponsorIRCCS Policlinico S. Donato

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-05-30

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