The Impact of an Antibiotic (Cefazolin) Before Surgery on the Microbiome in Patients With Stage I-II Melanoma

Inclusion Criteria: * Adult subjects with early stage melanoma (stage I-II) * Patients must be undergoing wide local excision +/- sentinel lymph node biopsy * Patients must be capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the consent form Exclusion Criteria: * Use of antibiotics within the three months prior to surgery * Allergy, sensitivity or anaphylaxis to beta-lactam or cephalosporin antibiotics * Presence of an infection at the time of surgery * Increased risk of infection due to a co-existing medical condition as determined by the surgical team or principal investigator (PI) * Subjects with a condition requiring systemic treatment with either corticosteroids (\> 10 mg daily prednisone equivalents) or other immunosuppressive medications within 14 days of study drug administration * American Society of Anesthesiologists (ASA) grade \> IV * Refusal to participate in the study * Patients who are pregnant will not be included in this study