Treat-to-Target Serum Urate Versus Treat-to-Avoid Symptoms in Gout

Exclusion criteria

• ✕. Diagnosis of CKD Stage 3B or worse (eGFR \< 45 mL/min/ 1.73 m2) at screening
• ✕. More than one subcutaneous tophus on clinical examination at screening
• ✕. Two or more episodes of renal colic in the past 5 years
• ✕. Unable to provide informed consent.
• ✕. AST/ALT \> 3 × upper limit of normal (ULN) (within 6 months of entry).
• ✕. Pregnancy, planning pregnancy, or breastfeeding.
• ✕. Patients who have been treated with thiopurines (mercaptopurine (PURINETHOL®), azathioprine (IMURAN®), or thioguanine) in the past 12 months or currently being treated with thiopurines are not eligible for the study. Usage of the thiopurines (azathioprine and mercaptopurine) with allopurinol has been shown to cause a significant drug-drug interaction.
• ✕. Unlikely to survive 2 years because of comorbidities.