The worldwide increase in the prevalence of obesity is a cause of great concern. Pharmacological treatment options are being explored at the moment with a major focus on the hormones produced by the gastrointestinal tract which regulate hunger and satiation/satiety. Modulating the release of these hormones via bitter substances reduced appetite-related sensations and gastrointestinal motility in lean female volunteers. Intragastric administration of a quinine-solution has shown to decrease hunger sensations in healthy female volunteers. Now, we want to examine whether this effect is still seen in an overweight female population.
Age range
18 Years – 65 Years
Sex
FEMALE
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To detect changes in consumed milkshake volume after acute administration of quinine hydrochloride compared to placebo.
Timeframe: 60 minutes after quinine hydrochloride or placebo infusion