Stopped: Financial support could not be obtained for the study
Hemodilution reduces concentrations of blood constituents: concentration of hemoglobin, red blood cells (hematocrit), physiological ions and coagulation factors that can contribute to impaired hemostasis and increasing the risk of perioperative blood transfusions. This pilot study will assess the feasibility of a large RCT to evaluate 2 techniques for reducing hemodilution during cardiac surgery: 1) retrograde autologous priming and 2) intraoperative mannitol. The aim of this pilot trial is to demonstrate feasibility of a larger trial to evaluate whether retrograde autologous priming and/or mannitol are superior to conventional priming alone.
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Feasibility Outcomes
Timeframe: Start to end of study recruitment, which is anticipated to take 20 weeks
Change in hemoglobin concentration during cardiopulmonary bypass
Timeframe: Start to end of cardiopulmonary bypass