Uterine Natural Killer (uNK) Cell Expression in Patients With Repeated ICSI Failures: A Multicent… (NCT04867759) | Clinical Trial Compass
UnknownNot Applicable
Uterine Natural Killer (uNK) Cell Expression in Patients With Repeated ICSI Failures: A Multicenter Cohort Study
Egypt120 participantsStarted 2021-05-01
Plain-language summary
uterine NK (uNK) cells are characterized by a high expression of CD56 (CD56brihgt), lack of CD16 expression, high secretion of cytokines and rather low cytotoxic activity. It has been shown that uNK cells increase in number during the late secretory phase and during early pregnancy. This study was designed to assess the possible role of uNK cells in repeated ICSI failure.
Who can participate
Age range
20 Years – 40 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients with IVF/ICSI failures more than 2 times
* Age 20-40 years
Exclusion Criteria:
* prior uterine surgery
* immunological disease
* previous testing to uNK cells
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Since this study is specifically looking at uterine natural killer cell levels in people with repeated ICSI failures, would measuring my uNK cells actually give us useful information about why my own embryo transfers haven't worked?
2This trial is listed as an observational cohort study — does that mean it's gathering data rather than testing a new treatment, and if so, would participating actually change anything about how my care is managed?
3The recruitment status for this trial is listed as 'unknown' — do you know if this study is still actively enrolling patients, and how would I even find out if I could take part?
4If my uNK cell levels turned out to be abnormal, are there any proven treatments based on that finding, or is the science still too early to guide real decisions about my next IVF or ICSI cycle?
5Before considering enrolling in a study like this, should I first explore other established reasons for repeated implantation failure — like uterine anatomy, embryo genetics, or clotting issues — that might already have treatment options available to me?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.