How Secreted-embryo-derived Trypsin Initiates, Maintains and Terminates Ca2+ Signals in Uterine Epithelial Cells

Inclusion Criteria: * Couples with primary / secondary infertility who are planned to undergo ICSI treatment with PGT-A * Age of each partner above 18 years Exclusion Criteria: * Couples with consanguinity (couple who is 1st or 2nd degree cousins) * Couples in whom the female partner has a history of: * Chemotherapy or radiation which impacts the ovarian reserve * Surgery at the ovaries / adnex region * Endometriosis * Couples in whom the male partner has a history of: * Chemotherapy / Radiation which impacts the semen result * Surgery at the testicles * Vasectomy * Surgery for reversal of vasectomy * Semen obtained by fine needle aspiration (FNA) or Testicular sperm extraction (TESE)