Oral Potentially Malignant Disorders: Comparison Between Surgical Treatment and Wait and See Approach

Inclusion Criteria: * OL diagnosis should be confirmed by incisional diagnostic biopsy and subsequent histopathological analysis * Subjects' age: 18 years or older * Lesions' size: 3 cm maximum longitudinal size of the single lesion * Lesions's location: oral areas with no surgical risk of damages to important anatomical structures such as nerves, salivary ducts and/or arteries. * Ability to understand and to sign a written informed consent document Exclusion Criteria: * Previous oral cancer * Head and neck radiotherapy * Subjects under the age of 18 * Subjects affected by PVL (proliferative verrucous leukoplakia) * High-risk of surgical damages to anatomical structures such as nerves, salivary ducts and/or arteries