RecruitingPhase 3

Preoperative Lugol's Solution in Graves' Disease and Toxic Nodular Goiter

Sweden182 participantsStarted 2021-11-18

Plain-language summary

The purpose of this study is to assess if preoperative treatment with Lugol's solution prior to thyroidectomy can reduce the surgical complications hypoparathyroidism and laryngeal nerve palsy

Who can participate

Age range18 Years – 75 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Hyperthyroidism accepted for thyroidectomy due to toxic nodular goiter with free T4 \<30 pmol/L or Graves' disease * Signed informed consent Exclusion Criteria: * Unstable coronary artery disease * Previous thyroid surgery * Congestive heart failure * Renal insufficiency * Hepatic failure * Current infection * Treatment with steroids or anticoagulants * Thyroid associated orbitopathy CAS \> 2 * Diabetes mellitus type 1 * Active cancer * Severe psychiatric illness * Amiodarone treatment * Pregnancy * Breast feeding * Women of child bearing potential not using contraceptive * Inability to comprehend the meaning of the study * Iodine hypersensitivity

What they're measuring

Temporary hypoparathyroidism

Timeframe: 1 month postoperatively

Trial details

NCT IDNCT04856488

SponsorJan Calissendorff

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2028-08

Contact for this trial

Jan Calissendorff, MD, PhD

+46(0)8 51770000 jan.calissendorff@regionstockholm.se

View on ClinicalTrials.gov More Hyperthyroidism trials