Detection of Plasma DNA Methylation in Peripheral Blood From Patients With Resectable Liver Cancer

Inclusion Criteria: * Patient has planned resection or ablation of suspected hepatocellular carcinoma * Patient is classified as resectable T1/T2 hepatocellular carcinoma (HCC) (solitary tumors less than or equal to 2 cm OR solitary tumors without vascular invasion \> 2cm or solitary tumor with vascular invasion \> 2cm, or multiple tumors, none \> 5cm) OR BCLC stage A (Single lesion of ANY size or 3 nodules or less with each being 3cm or less) Exclusion Criteria: * Patient is younger than 18 years of age * Females who are pregnant or attempt to become pregnant * Patient with significant anemia (hemoglobin \[Hb\] \< 7g/dL) * Patient has known cancer outside of the liver 5 years prior to current blood collection (not including basal cell or squamous cell skin cancers) * Patient has had a biopsy to the target organ and/or lesion within 3 days before blood collection * Patient has had an intervention to completely remove current target pathology * Target pathology is a recurrence of previously treated HCC * Patient has had prior resection or ablation for target lesion * Patient has had prior or active chemotherapy or radiation for target lesion