Not Yet RecruitingEarly Phase 1

THC + CBD and Memory Study

9 participantsStarted 2025-12-01

Plain-language summary

Memory deficits are one of the most consistently observed cognitive effects of marijuana use. There is evidence that some decrements attributable to the primary psychoactive ingredient, delta-9-tetrahydrocannabinol (THC), may be attenuated by cannabidiol (CBD). This study will help us learn more about the relationship between THC and CBD consumption with memory processes. A combination of MRI and neuropsychological tests (which are computer and paper/pencil tasks) will be used to measure the neurocognitive and behavioral impacts of THC and CBD use.

Who can participate

Age range18 Years – 40 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Right-handed * Prior MJ users (has used MJ at least once in the past year, but no more than 1x/month in the past 12 months) * Medically healthy (as determined by medical history and treatment) * Adequate comprehension of English in order to complete study materials * Acceptable birth control method for women (i.e., no copper IUD or any device that is not MRI safe) Exclusion Criteria: * Participant currently uses psychoactive medications or substances * Psychiatric diagnoses (determined by DSM-V) * Participant heavily or regularly uses MJ (more than 1x/month in the past year) * Current or past substance dependence (including MJ) * Positive urine toxicology screens * Positive pregnancy screens * MRI contraindications (e.g., heart pacemaker)

What they're measuring

fMRI response

Timeframe: approximately 1 hour following drug administration

Glutamate

Timeframe: approximately 1 hour following drug administration

Trial details

NCT IDNCT04855526

SponsorHartford Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-12-30

Contact for this trial

Chelsea N Meagher, BA

860-545-7106 chelsea.meagher@hhchealth.org