CompletedPhase 1/2

Opioid Modulation and Neural Reward Activation in Healthy Adults

United States13 participantsStarted 2021-05-01

Plain-language summary

This is a double blind study of the effects of opioid antagonism on the brain's reward response. The investigators will recruit participants to undergo two scans, one on active medication and one on placebo. During the scan, the investigators will assess reward.

Who can participate

Age range18 Years – 35 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Between 18 and 35 years of age, * Is a moderate drinker (i.e. consumes 1-14 drinks/week for males, or 1-7 drinks/week for females). Exclusion Criteria: * Non-drinker * Positive result on urine drug screen or breathalyzer at the start of any study visit * Inability to complete MRI (e.g. presence of ferromagnetic objects in body) * Current use of medications that alter the hemodynamic response such as insulin * History of trauma resulting in loss of consciousness longer than 15 minutes * Currently taking opioid medications * Pregnancy

What they're measuring

Change in Brain Activation to Reward Between Placebo and Active Medication

Timeframe: one week

Trial details

NCT IDNCT04854551

SponsorUniversity of Colorado, Denver

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-04-18

Results submitted2023-05-15

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