Investigation of Chronic Obstructive Pulmonary Disease (COPD) Phenotypes and Endotypes in China

Inclusion criteria: * Male or female participants, aged 50-80 years inclusive. A female is eligible only if she is of non-child bearing potential. * Body mass index (BMI) less than (\<)35. * A signed and dated written informed consent is obtained prior to participation. Additional inclusion criteria for COPD participants: * A Baseline (post-bronchodilator) (FEV1/FVC) ratio \<70 percent (%). * Clinically stable and has no exacerbations for at least 1 month prior to recruitment. * Ever smoker or never smoker. Additional inclusion criteria for chronic bronchitis participants: * Free from other significant diseases. * Baseline post-bronchodilator FEV1/FVC ratio more than (\>)70%. * Chronic bronchitis is defined as at least 3 months of cough and phlegm in a year in the past 2 years. * Clinically stable and has no exacerbations for at least 1 month prior to recruitment. * Ever smoker or never smoker Additional inclusion criteria for healthy participants: * Free from any significant diseases * Baseline post-bronchodilator FEV1/FVC ratio \>70%. * A CAT score \<10. * Never smoker. Passive smoker is not eligible. Exclusion criteria: * Having undergone lung surgery. * Known respiratory disorders or significant inflammatory disease other than COPD. * Serious, uncontrolled disease (including serious psychological disorders) * Confirmed cancer, unless participants in remission for more than or equal to (\>=)5 years. * Participating or plan to participant in any clinical studies wh…