The Effect of Modified Radical Endoscopic Sinus Surgery on Eosinopilic Chronic Rhinosinusitus With Nasal Polyps

Inclusion Criteria: * CRSwNP is diagnosed according to EPOS clinical guidelines and met surgical requirements, the blood eosinophil count was greater than 0.22; * Subjects/legal authorized representatives must understand the purpose and procedures of the study and voluntarily sign the informed consent, voluntarily participate in the study and comply with the study regulations, understand and comply with follow-up plan, and can correctly record the scale score, the administration frequency, accompanying drug use and adverse events, etc; * The examinee must be 18-65 years old, male or non pregnant female, limited to Chinese; * During the treatment and follow-up period, female subjects have no pregnancy and lactation plans; * The subjects did not participate in other clinical trials in the past three months and agreed not to participate in other clinical trials before reaching the end point of this trial; * Patients accompanying asthma must use their regular asthma treatment steadily in the past 6 weeks; Exclusion Criteria: * Women must not be pregnant, or breast-feeding; * Subjects with cystic fibrosis, congenital ciliary dyskinesia, fungal sinusitis, systemic vasculitis and granulomatous disease, tumor, and immunodeficiency are exclued; * Subjects accpted nasal endoscopic surgery within 6 months are exclued; * Subjects with an upper respiratory tract infection within 4 weeks of entering the study are excluded; * Subjects with serious metabolic, cardiovascular, autoimmune, n…