Do Adolescents and Adults Differ in Their Acute Response to Cannabis?

Inclusion Criteria: * Adolescents: Aged 16-17 * Adults: Aged 26-29 years * Self-reported cannabis use between 0.5 and 3 days/week, averaged over the last 3 months * Adults: Body mass index (BMI) between 18.5 and 29.9 * Adolescents: BMI between 2nd percentile and 98th percentile * Self-reported ability to consume approximately half a typical joint of cannabis by themselves within 20 minutes * Willing to be cannulated and have four blood samples taken at every acute session * Right-handed Exclusion Criteria: * Females: Pregnant or breast-feeding * Adults: Before the age of 18, had a period of 3 or more months when cannabis was used once per week or more frequently. * Severe cannabis use disorder (DSM-5) * Illicit drug use of any specific drug more than twice per month, averaged over the last 3 months * Receiving treatment (pharmacological or psychological) for a mental health problem within the last month * Lifetime psychosis * Lifetime psychosis of any immediate family member * Hypertension (systolic \> 160 or diastolic \> 100) * Dependent on tobacco or vaping nicotine (\> 1 on the Heaviness of Smoking Index) * Currently taking a psychotropic medication that will likely affect dependent variables or interact with cannabis * Any physical or mental health condition, any medication, or any treatment, that the study doctor considers to be an exclusion * MRI contraindications * Significant asthma or respiratory problems - severity judged clinically * Self-reported moderate/sever…