Neural Mechanisms of Immersive Virtual Reality in Chronic Pain

Inclusion Criteria: * Age (18-88 years) * English speaker (written and spoken) * Temporal Mandibular Disorder (TMD) for at least 3 months Exclusion Criteria: * Present or past degenerative neuromuscular disease * Cardiovascular, neurological diseases, pulmonary abnormalities, kidney disease, liver disease, history of cancer within past 3 years * Cervical pain other than TMD related (e.g. stenosis, radiculopathy) * Any personal (or family first degree) history of mania, schizophrenia, or other psychoses * Severe psychiatric condition (e.g., schizophrenia, bipolar disorders, autism) leading to hospitalization within the last 3 years. * Use of antidepressants, ADHD medication, non-over-the-counter painkillers, methadone, benzodiazepines, barbiturates, and/or narcotics during the past 3 months * Lifetime alcohol/drug dependence or alcohol/drug abuse in the past 3 months * Pregnancy or breastfeeding * Color-blindness * Pain in jaw or temple in last 3 months due to toothache or infection * Any facial trauma that has occurred in the last 6 weeks * History of severe facial trauma in the last 3 months * Impaired or uncorrected hearing * Conditions that would interfere with the VR mask placement (e.g. trauma, burn, infection) * Known history of severe motion sickness * High blood pressure or symptomatic low blood pressure * History of fainting * History of angioedema * Failed drug test (testing for opiates, cocaine, methamphetamines, amphetamines, and THC)