CompletedPhase 1/2

Effects of Tradipitant on Satiation, Gastric Volume, Gastric Accommodation, and Gastric Emptying in Healthy Volunteers

United States27 participantsStarted 2021-02-01

Plain-language summary

To evaluate the effects of tradipitant relative to placebo on satiation, gastric volume, gastric accommodation, and gastric emptying in healthy volunteers.

Who can participate

Age range18 Years – 65 Years

SexALL

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Inclusion Criteria: * Able to provide written consent * Body Mass Index (BMI) of 18-35 kg/m2 * No medical problems or chronic diseases Exclusion Criteria: * Diagnosis of gastrointestinal diseases * Structural or metabolic diseases that affect the GI system * A positive test for drugs of abuse at screening

What they're measuring

Fasting Gastric Volume as Measured by Single Photon Emission Computed Tomography (SPECT)

Timeframe: 9 Days

Accommodation Volume as Measured by SPECT

Timeframe: 9 Days

Satiation Expressed as Volume to Fullness as Measured by Satiation Test

Timeframe: 9 Days

Gastric Emptying Half-time of Solids as Measured by Scintigraphy

Timeframe: 9 Days

Trial details

NCT IDNCT04849559

SponsorVanda Pharmaceuticals

Sponsor typeINDUSTRY

Study typeINTERVENTIONAL

Primary completion2021-09-24

Results submitted2024-03-19

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