Exploring Muscle Breakdown During Exercise Recovery
United Kingdom26 participantsStarted 2021-04-08
Plain-language summary
This study will allow researchers to explore how muscle responds to heavy exercise. The researchers will characterise rates of muscle protein breakdown and synthesis 24hours after heavy exercise with a post exercise protein polyphenol or placebo supplementation. This will inform strategies to help people recover from heavy exercise.
Who can participate
Age range18 Years – 40 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Recreationally active
* 18-40 years of age
Exclusion Criteria:
* Regular and structured involvement in resistance training
* Inactive participants
* Habitual dietary protein intake \<0.8g/kg bw/day and \>2.0g/kg bw/day
* Regular use of nutritional supplements known to suppress inflammation or modulate protein metabolism Any diagnosed metabolic conditions (diabetes), cardiovascular disease or hypertension
* Current musculoskeletal injury
* Chronic use of anti-inflammatory medicines
* Any known disorders in muscle metabolism
* Individuals with an allergy to egg, fish, wheat or soy ingredients as the product is manufactured in a facility that contains these ingredients
* Allergy to lidocaine
* Having received or ingested a stable isotope tracer containing 15N in the past
* A personal or family history of epilepsy, seizures or schizophrenia
* Stomach bleeding or stomach ulcer
* Kidney failure
* Liver problems, such as fibrosis, cirrhosis or failure
* Crohns disease or ulcerative colitis
* Chickenpox or shingles
* Pregnant or trying to get pregnant
* Any diagnosed cardiovascular disease (e.g. deep vein thrombosis) or hypertension.
* Any diagnosed metabolic impairment (e.g. type 1 or 2 Diabetes)
* Recent (within the last 6 months) or current musculoskeletal injury (leg fracture)