SuspendedNot Applicable

Neurosensory Abnormalities in SymptomAtic Ocular Surface Patients (NASA)

Stopped: PI is leaving insitution. This study is no longer active at TMC.

United States1,000 participantsStarted 2021-07-02

Plain-language summary

This study is designed to measure how common nerve abnormalities are within a group of patients who feel discomfort within their eyes.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Presents with ocular surface discomfort or for dry eye care * Best corrected visual acuity of 20/40 or better in each eye * Subject reported duration of symptoms of at least 3 months * 100 subjects will be required to be habitual contact lens wearers as defined by use of contact lenses at least 5 hours per day at least 5 days per week for the last year. Exclusion Criteria: * Use of contact lenses on the day of the visit * Pregnant or nursing * Irregular corneas (e.g., ectatic disease, transplantation, or corneal dystrophies) * Ocular surgery in the past 3 months * Ocular infection in the past 3 months * Active ocular allergies

What they're measuring

To establish the prevalence of neuropathic corneal pain in patients with ocular surface discomfort.

Timeframe: Day 1

To assess the overlap of neuropathic corneal pain with dry eye disease in patients in diseases that are currently thought to be mutually exclusive.

Timeframe: Day 1

To establish the prevalence of subtypes of patients with neuropathic corneal pain or with a neuropathic component of dry eye in patients with ocular surface discomfort.

Timeframe: Day 1

Trial details

NCT IDNCT04838223

SponsorTufts Medical Center

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-12-31

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