SuspendedNot Applicable

Neurosensory Abnormalities in SymptomAtic Ocular Surface Patients (NASA)

Stopped: PI is leaving insitution. This study is no longer active at TMC.

United States1,000 participantsStarted 2021-07-02

Plain-language summary

This study is designed to measure how common nerve abnormalities are within a group of patients who feel discomfort within their eyes.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Presents with ocular surface discomfort or for dry eye care * Best corrected visual acuity of 20/40 or better in each eye * Subject reported duration of symptoms of at least 3 months * 100 subjects will be required to be habitual contact lens wearers as defined by use of contact lenses at least 5 hours per day at least 5 days per week for the last year. Exclusion Criteria: * Use of contact lenses on the day of the visit * Pregnant or nursing * Irregular corneas (e.g., ectatic disease, transplantation, or corneal dystrophies) * Ocular surgery in the past 3 months * Ocular infection in the past 3 months * Active ocular allergies

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

To establish the prevalence of neuropathic corneal pain in patients with ocular surface discomfort.

Timeframe: Day 1

To assess the overlap of neuropathic corneal pain with dry eye disease in patients in diseases that are currently thought to be mutually exclusive.

Timeframe: Day 1

To establish the prevalence of subtypes of patients with neuropathic corneal pain or with a neuropathic component of dry eye in patients with ocular surface discomfort.

Timeframe: Day 1

Trial details

NCT IDNCT04838223

SponsorTufts Medical Center

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-12-31

View on ClinicalTrials.gov More Dry Eye trials

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

To establish the prevalence of neuropathic corneal pain in patients with ocular surface discomfort.

Timeframe: Day 1

To assess the overlap of neuropathic corneal pain with dry eye disease in patients in diseases that are currently thought to be mutually exclusive.

Timeframe: Day 1

To establish the prevalence of subtypes of patients with neuropathic corneal pain or with a neuropathic component of dry eye in patients with ocular surface discomfort.

Timeframe: Day 1