Thrombocytopenia is an important pathological feature of HFRS（Hemorrhagic Fever With Renal Syndrome, HFRS）. However, the cause of thrombocytopenia in HFRS is not yet fully understood. Neutrophils, as the largest number of white blood cells in the human body, can widely participate in the immune process of viral infections. Previous studies have found that the neutrophils of patients with acute myocardial infarction can interact with activated platelets and further mediate platelet phagocytosis.Therefore, this study aims to systematically elucidate the immunological process of neutrophil mediated thrombocytopenia in patients with HFRS by exploring the correlation between platelet activation, neutrophil activation and neutrophil proportion of adherent / phagocytic platelets peripheral blood of HFRS patients, and to analyze its relationship with the course of HFRS disease, which lays a theoretical foundation for further understanding the pathogenesis of HFRS and provides a basis for clinical use.
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Changes in the platelet activation ratio, %
Timeframe: through study completion, an average of 2 year
Changes in neutrophils MPO content, MFI
Timeframe: through study completion, an average of 2 year
Changes in the neutrophils with adherent platelets, %
Timeframe: through study completion, an average of 2 year
Changes in the neutrophils with internalized platelets, %
Timeframe: through study completion, an average of 2 year