Evaluation of New Diagnostic Indicator of Subclinical Hypercortisolism

Inclusion Criteria: * patients with adrenal accidental tumor (diameter \> 1cm) found by physical examination or imaging examination due to non-adrenal diseases Exclusion Criteria: * concomitant use of drugs influencing glucocorticoid metabolism or secretion * major psychiatric illness or history of excess alcohol intake * overt clinical features of hypercortisolism * clinical and endocrine function evaluation (surgery patients at the same time reference to postoperative pathology) revealed primary aldosteronism, pheochromocytoma, adrenocortical carcinoma, adrenal metastasis of cancer, myelolipoma; oncocytoma, congenital adrenal cortex hyperplasia and ganglion cells neuroma/paraganglioma, schwannoma, adrenal hematoma and uncertain diagnosis) * non-adenoma lesions such as cysts and hemorrhage * The pregnancy * Patients with severe underlying diseases (such as liver and kidney failure, acute severe infection, etc.) that may affect the function of the hypothalamus-pituitary-adrenal axis (HPA axis)