UnknownNot Applicable

Study of the Role of Hemostasis in Perioperative Anaphylaxis

30 participantsStarted 2021-04-01

Plain-language summary

Anaphylaxis is a severe and life-threatening complication during the perioperative period. Perioperative anaphylaxis is still associated with a significant mortality despite quick and efficient management using epinephrine, the mainstay of acute treatment. Experimental data and few case reports are suggesting that hemostasis, and more precisely platelets, could play a role in anaphylaxis. Our main hypothesis is that activation of the hemostatic system contributes to the severity of the reaction

Who can participate

Age range2 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patient, male or female, adult * In the perioperative period * In whom the diagnosis of anaphylactic shock is suggested * Patient is giving his consent to participate in the study Exclusion Criteria: * Subject under legal protection * Subject under guardianship or guardianship * Anemia less than 7 g /dl at the time of inclusion

What they're measuring

Platelet activation

Timeframe: As soon as possible after onset of anaphylaxis

Platelet activation

Timeframe: 1-2 hours after the onset of anaphylaxis

Platelet activation

Timeframe: 24 hours after the onset of anaphylaxis

Platelet activation

Timeframe: During the allergic workup (4-6 weeks after)

Trial details

NCT IDNCT04825158

SponsorUniversity Hospital, Strasbourg, France

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2021-04-01

Contact for this trial

Charles-Ambroise TACQUARD, PHD

+333 69 55 16 08 charlesambroise.tacquard@chru-strasbourg.fr

View on ClinicalTrials.gov More Hemoptysis trials