The Use of Injectable Plasma Versus the Use of Simvastatin Gel in Surgical Management of Bony Defect in Dentistry

Inclusion Criteria: * • Age range between 25 and 40 years * Patients with severe chronic periodontitis having probing depth (PD) ≥6 mm and clinical attachment loss (CAL) ≥5 mm , or Stage III periodontitis * Patient having vertical bone loss ≥3 mm (distance between alveolar crest and base of the defect as confirmed by preoperative intraoral periapical radiographs using standardized parallel technique.) * Good compliance with the plaque control instructions following initial therapy * Availability for follow up and maintenance program. Exclusion Criteria: * • Patient with any systemic disease or conditions * Patient using antibiotic, anti-inflammatory, and immunosuppressive therapy during the preceding 3 months before the start of trial and during the study. * Patients who have undergone any periodontal treatment in the last 6 months * Pregnant and Lactating. * Reported allergy to any type of statins * Subjects who were tobacco or alcohol users * Vulnerable group of patients (e.g.: prisoners , handicapped , or decisionally impaired individuals )