Clotting Parameters After Medical Abortion (NCT04824118) | Clinical Trial Compass
CompletedNot Applicable
Clotting Parameters After Medical Abortion
United Kingdom45 participantsStarted 2021-03-26
Plain-language summary
Venous thromboembolism (VTE - blood clots that form in deep veins or in the lungs) has been identified as a leading cause of death in economically developed countries for pregnant and recently-pregnant women.
There is evidence that clotting parameters can take up to 6 weeks to return to normal for women who have had term deliveries, however there is an absence of information on time taken for clotting parameters to normalise following abortion.
As such, existing guidelines are based solely on expert opinion and recommend durations of VTE prevention from as short as 7 days, up to 6 weeks following abortion.
All women are assessed for risk of VTE, but data are needed to inform an evidence-based approach to prevention of VTE in these women.
The findings from this pilot study have the potential to inform clinical guidance and possibly a larger study subsequently.
Who can participate
Age range
16 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
Group 1:
* Pregnant and seeking abortion
* Gestation of pregnancy less than 10 weeks
* Healthy, no medical conditions
Group 2:
* Pregnant and seeking abortion
* Gestation of pregnancy between 10 and 14 weeks
* Healthy, no medical conditions
Group 3:
* Pregnant and seeking abortion
* Gestation of pregnancy between 14 to 20 weeks
* Healthy, no medical conditions
Group 4:
* Non pregnant
* Healthy, no medical conditions
* Able to speak English independently
Exclusion Criteria:
All groups:
* Unable to give informed consent
* Previous or current venous thromboembolism
* Current smoker
* Personal or family history of thrombophilia or haemophilia
* Taking medicines known to affect clotting parameters (e.g. Aspirin)
Groups 1-3:
\- Planning to commence hormonal contraception prior to second blood test.
Group 4:
\- Using hormonal contraception at baseline visit
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.