Effect of Low Intensity Training Combined With Partial Restriction of Blood Flow in Individuals W… (NCT04819672) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Effect of Low Intensity Training Combined With Partial Restriction of Blood Flow in Individuals With Knee Osteoarthritis
66 participantsStarted 2024-10-05
Plain-language summary
Osteoarthritis (OA) is a chronic degenerative infection that presents clinical features such as pain and limited range of motion. A weakness of the quadriceps makes this joint more susceptible to wear and tear to the articular cartilage, especially in the medial compartment of the knee. As a result, it is necessary to promote an increase of at least 30% in quadriceps strength for a beneficial effect on pain and 40% in functional capacity. Therapeutic exercises are used to increase strength muscle, in addition to high intensity exercises, to decrease joint pain, low to moderate intensity resistance training has been included, with the new approach of using partial blood flow restriction.
Who can participate
Age range
50 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Confirmation of clinical diagnosis of osteoarthritis according to the criteria established by the American College of Rheumatology;
* OA knee radiograph grades 2 - 4 according to the Kellgren-Lawrence scale;
* Reporting knee pain with minimum intensity of 3 on Numerical Pain Scale;
* Complaints of pain and functional reduction in the last three months;
Exclusion Criteria:
* Diabetes type I or decompensated;
* Peripheral vascular disease;
* Uncontrolled hypertension;
* History of deep vein thrombosis;
* History of stroke;
* History of cancer;
* Cardiac pacemaker;
* Cognitive disorders;
* Neurological deficits (sensory or motor)
* Body mass index above 40 kg/m2
* Hip symptomatic osteoarthritis
* Low back pain
* Use of painkillers in the last 24 hours;
* Intra-articular infiltration with hyaluronic acid and corticosteroids in the last 6 months;
* Orthopedic surgery on lower limbs;
* Systemic inflammatory disease;
* Not able to walk
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Pain subscale - Knee Injury and Osteoarthritis Outcome Score
Timeframe: 8-week follow-up
2
Activities of daily living subscale - Knee Injury and Osteoarthritis Outcome Score