CompletedNot Applicable

COVID-19 Associated Pulmonary Aspergillosis (CAPA) and Other Invasive Fungal Infections (IFI)

United States219 participantsStarted 2021-03-09

Plain-language summary

The purpose of this study is to identify the number of individuals with severe CoVID who require ventilator support and who develop serious fungal infections. The study is an observational study, meaning that we are not providing any intervention that does not involve usual standard of care. Our chief goal is to find evidence of fungal infection by using traditional, approved methods of diagnosis, but by applying these methods in the same way and frequency among all study participants. We will be looking especially for evidence of a fungal infection known as Aspergillus, which can causes a serious lung infection called invasive aspergillosis (IA).

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adults aged 18 years or older at the time of enrollment * SARS-COV2 positivity by PCR with respiratory failure requiring mechanical ventilation for at least 72 hours * Prior therapy with antifungals, including prophylaxis, is NOT an exclusion. Exclusion Criteria: * Life expectancy of less than 72 hours as determined by the site investigator. * Expected to be weaned from mechanical ventilation in next 24 hours * Care received in any setting other than an intensive care unit (ICU) at the time of enrollment

What they're measuring

Participants requiring mechanical ventilation

Timeframe: 72 hours or greater

Participants with all cause mortality

Timeframe: In 30 days

Participants with all cause mortality

Timeframe: In 60 days

Trial details

NCT IDNCT04818853

SponsorUniversity of Alabama at Birmingham

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2022-07-20

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