Combined Intravenous Dexamethasone and Dexmedetomidine as Adjuncts to Popliteal and Saphenous Nerve Blocks in Patients Undergoing Orthopaedic Surgery of the Foot and Ankle

Inclusion Criteria: * Scheduled for unilateral osseous surgery of the ankle or foot * General anaesthesia with both a popliteal and a saphenous nerve block for postoperative analgesia * Age of 18 or above * American Society of Anaesthesiologists Physical Status Score of 1 to 3 * Body Mass Index of 18 to 40, but a minimum weight of 50 kg. * For fertile women, negative urine humane choriongonadotropine test and use of safe anti-conception * Ability to understand the trial protocol, risks, benefits, and provide signed informed consent Exclusion Criteria: * Inability to read and understand Danish * Uncooperativeness (as judged by investigators) * Participation in another trial involving medication * Allergy to study medication * Daily use of opioids above 30 mg/day morphine (or equivalents) * Daily use of corticosteroids of more than 5 mg prednisolone equivalents within the past one month * Neurological or musculoskeletal disease making block performance impossible (as judged by investigators) * Dysregulated diabetes (as judged by investigators) * Dysregulated anticoagulants (as judged by investigators) * History of drug or alcohol abuse * Glaucoma * Contraindications for paracetamol or opioids * Contraindications to general anaesthesia * Other concomitant conditions needing surgery * Other concomitant traumatic injuries