Not Yet RecruitingNot Applicable

Characterization of the Corneal Biomechanics of Patients Treated by Corneal Lenticule Extraction for Advanced Refractive Correction (CLEAR) to Correct Myopia

Switzerland100 participantsStarted 2026-06-01

Plain-language summary

This study aims to perform biomechanical tests on extracted CLEAR lenticles that are routinely discarded after surgery. The investigators also aim to perform Brillouin microscopy to get an in-vivo assessment of the patient's cornea preoperatively and to correlate this data with the postoperative characterization of the extracted corneal lenticule. The characterization will be done with established biomechanical and morphologic tests.

Who can participate

Age range20 Years – 50 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients scheduled for CLEAR procedures for myopia (range: \>-3D with an astigmatism \<0.25D) in the age group 20-50 years. * Willing and able to return for scheduled follow-up examinations * Able to provide written informed consent and follow study instructions in English or German Exclusion Criteria: * Irregular corneal topo-/tomography (Asymmetry \>1.0D within the inner 5mm) * Previous intraocular or corneal surgery of any kind in the eye to be treated, including any type of surgery for either refractive or therapeutic purposes. * History of steroid-responsive rise in intraocular pressure, glaucoma, or preoperative intraocular pressure (IOP) \> 21 mmHg in either eye. * History of diabetes, diagnosed autoimmune disease, connective tissue disease or clinically significant atopic syndrome.

What they're measuring

Biomechanics of extracted lenticule

Timeframe: 1 year

Trial details

NCT IDNCT04817592

SponsorUniversity of Bern

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2027-06-01

Contact for this trial

Philippe Büchler, Prof. Dr.

+41 31 684 14 10 philippe.buechler@unibe.ch