Pharmacokinetics, Safety, and Tolerability of SYN-020

Exclusion criteria

• . Subject has a history or the presence of clinically significant cardiovascular, pulmonary, hepatic, renal, hematologic, gastrointestinal, endocrine, immunologic, dermatologic, neurologic, oncologic, vascular, metabolic, collagen, or psychiatric disease or any other condition that, in the opinion of the Investigator, would jeopardize the safety of the subject or the validity of the study results.
• . Subject has any known malabsorption syndrome or history of gastrointestinal surgery that could compromise the study objectives.
• . Subject has used any medication (prescription or non-prescription) or herbal supplement, other than prescription hormone replacement therapy (eg, thyroid, testosterone, estrogen) or contraception methods described in Inclusion Criterion #6, within 21 days before Day -1.
• . Subject is pregnant, breastfeeding, or not using a medically accepted method of contraception.
• . Subject is unable to abstain from artificial sweeteners (eg, aspartame, acesulfame potassium, advantame, saccharin, stevia, and sucralose) from CRU admission to the end of study participation.
• . Subject has a positive urine drug or alcohol test at Screening or CRU admission OR has a history of drug/alcohol abuse within 12 months before Screening.
• . Subject has donated more than 500 mL blood during the 3-month period before Day -1.
• . Subject has known intolerance of study drug/ingredients.